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Phenotypes Associated with This Genotype
Genotype
MGI:3530641
Allelic
Composition
Lcattm1Nsa/Lcat+
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcattm1Nsa mutation (1 available); any Lcat mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• on a regular chow diet, heterozygotes show a moderate reduction in the APOA1 containing HDL particles present in plasma relative to wild-type
• on a regular chow diet, the very low density lipoprotein fractions from heterozygotes are enriched in triglycerides
• the plasma concentrations of apoA-I of fasted heterozygotes are significantly reduced relative to wild-type levels
• in heterozygotes, the plasma concentrations of total cholesterol are significantly reduced relative to wild-type male and female levels
• the cholesteryl ester/total cholesterol ratio in heterozygous mutant and wild-type mice are 78-83% and 79-81%, respectively
• in heterozygotes, the plasma concentrations of HDL cholesterol are significantly reduced relative to wild-type levels
• in male heterozygotes, plasma triglyceride concentrations are 49% higher than those of wild-type males
• in female heterozygotes, triglyceride levels are not significantly different from those of wild-type females

Mouse Models of Human Disease
OMIM ID Ref(s)
Lecithin:cholesterol Acyltransferase Deficiency 245900 J:39237


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory