Mouse Genome Informatics
ht
    Lcattm1Nsa/Lcat+
involves: 129X1/SvJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• on a regular chow diet, heterozygotes show a moderate reduction in the APOA1 containing HDL particles present in plasma relative to wild-type
• on a regular chow diet, the very low density lipoprotein fractions from heterozygotes are enriched in triglycerides
• the plasma concentrations of apoA-I of fasted heterozygotes are significantly reduced relative to wild-type levels
• in heterozygotes, the plasma concentrations of total cholesterol are significantly reduced relative to wild-type male and female levels
• the cholesteryl ester/total cholesterol ratio in heterozygous mutant and wild-type mice are 78-83% and 79-81%, respectively
• in heterozygotes, the plasma concentrations of HDL cholesterol are significantly reduced relative to wild-type levels
• in male heterozygotes, plasma triglyceride concentrations are 49% higher than those of wild-type males
• in female heterozygotes, triglyceride levels are not significantly different from those of wild-type females

Mouse Models of Human Disease
OMIM IDRef(s)
Lecithin:cholesterol Acyltransferase Deficiency 245900 J:39237