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Phenotypes Associated with This Genotype
Genotype
MGI:3530074
Allelic
Composition
Atrxtm1Rjg/Y
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atrxtm1Rjg mutation (0 available); any Atrx mutation (75 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutant males die within 24 - 48 hours of birth, with only 1 male surviving to 24 days of age

behavior/neurological
• mutant males lack milk in their stomachs
• mutant males do not suckle well

growth/size/body
• mutants are smaller at birth

nervous system
• the dentate gyrus is replaced by a mass of disorganized cells
• reduced numbers of CA1 and CA3 pyramidal neurons are seen
• the subiculum and hippocampus are reduced in size
• the frontal cortex is reduced in size especially in the caudal-medial cortex and cell density is decreased in the cortex as a result of increased cell death and not a change in proliferation
• cell numbers in the cortical plate are reduced by 20-30%
• cell loss is not seen at E13.5 but is significant at E15.5


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory