Mouse Genome Informatics
cn
    Atrxtm1Rjg/Y
Foxg1tm1(cre)Skm/Foxg1+

involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mutant males die within 24 - 48 hours of birth, with only 1 male surviving to 24 days of age (J:95953)

behavior/neurological
• mutant males lack milk in their stomachs (J:95953)
• mutant males do not suckle well (J:95953)

growth/size/body
• mutants are smaller at birth (J:95953)

nervous system
• the dentate gyrus is replaced by a mass of disorganized cells (J:95953)
• reduced numbers of CA1 and CA3 pyramidal neurons are seen (J:95953)
• the subiculum and hippocampus are reduced in size (J:95953)
• the frontal cortex is reduced in size especially in the caudal-medial cortex and cell density is decreased in the cortex as a result of increased cell death and not a change in proliferation (J:95953)
• cell numbers in the cortical plate are reduced by 20-30% (J:95953)
• cell loss is not seen at E13.5 but is significant at E15.5 (J:95953)

Mouse Models of Human Disease
OMIM IDRef(s)
Alpha-Thalassemia/Mental Retardation Syndrome, X-Linked; ATRX 301040 J:95953