Mouse Genome Informatics
hm
    Vangl2Lp/Vangl2Lp
involves: CBA/Ca * LPT/Le
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• marked broadening and flattening of the neural plate ventral midline at E8.5
• fail to develop a sharp midline bending at E8.5
• failure to initiate neural tube closure at the cervical/hindbrain boundry
• neural tube is open throughout the hindbrain and spinal region

embryogenesis
N
• more anterior neural fold development is more like controls (J:47700)
• marked broadening and flattening of the neural plate ventral midline at E8.5
• fail to develop a sharp midline bending at E8.5
• failure to initiate neural tube closure at the cervical/hindbrain boundry
• neural tube is open throughout the hindbrain and spinal region
• enlarged
• loosely organized
• poorly condensed
• irregularly shaped

skeleton
• sternal defects
• multiple rib fusions
• neural arches are unfused dorsally
• unfused arches are splayed apart

Mouse Models of Human Disease
OMIM IDRef(s)
Neural Tube Defects 182940 J:47700