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Phenotypes Associated with This Genotype
Genotype
MGI:3529938
Allelic
Composition
Vangl2Lp/Vangl2Lp
Genetic
Background
involves: CBA/Ca * LPT/Le
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vangl2Lp mutation (2 available); any Vangl2 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• marked broadening and flattening of the neural plate ventral midline at E8.5
• fail to develop a sharp midline bending at E8.5
• failure to initiate neural tube closure at the cervical/hindbrain boundry
• neural tube is open throughout the hindbrain and spinal region

embryo
N
• more anterior neural fold development is more like controls
• marked broadening and flattening of the neural plate ventral midline at E8.5
• fail to develop a sharp midline bending at E8.5
• failure to initiate neural tube closure at the cervical/hindbrain boundry
• neural tube is open throughout the hindbrain and spinal region
• enlarged
• loosely organized
• poorly condensed
• irregularly shaped

skeleton
• sternal defects
• multiple rib fusions
• neural arches are unfused dorsally
• unfused arches are splayed apart

Mouse Models of Human Disease
OMIM ID Ref(s)
Neural Tube Defects, Susceptibility To; NTD 182940 J:47700


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory