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Phenotypes Associated with This Genotype
Genotype
MGI:3529938
Allelic
Composition
Vangl2Lp/Vangl2Lp
Genetic
Background
involves: CBA/Ca * LPT/Le
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vangl2Lp mutation (2 available); any Vangl2 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• marked broadening and flattening of the neural plate ventral midline at E8.5 (J:47700)
• fail to develop a sharp midline bending at E8.5 (J:47700)
• marked broadening and flattening of the neural plate ventral midline at E8.5 (J:47700)
• fail to develop a sharp midline bending at E8.5 (J:47700)
• failure to initiate neural tube closure at the cervical/hindbrain boundry (J:47700)
• neural tube is open throughout the hindbrain and spinal region (J:47700)
• failure to initiate neural tube closure at the cervical/hindbrain boundry (J:47700)
• neural tube is open throughout the hindbrain and spinal region (J:47700)

embryogenesis
N
• more anterior neural fold development is more like controls (J:47700)
• more anterior neural fold development is more like controls (J:47700)
• marked broadening and flattening of the neural plate ventral midline at E8.5 (J:47700)
• fail to develop a sharp midline bending at E8.5 (J:47700)
• marked broadening and flattening of the neural plate ventral midline at E8.5 (J:47700)
• fail to develop a sharp midline bending at E8.5 (J:47700)
• failure to initiate neural tube closure at the cervical/hindbrain boundry (J:47700)
• neural tube is open throughout the hindbrain and spinal region (J:47700)
• failure to initiate neural tube closure at the cervical/hindbrain boundry (J:47700)
• neural tube is open throughout the hindbrain and spinal region (J:47700)
• enlarged (J:47700)
• loosely organized (J:47700)
• enlarged (J:47700)
• loosely organized (J:47700)
• poorly condensed (J:47700)
• poorly condensed (J:47700)
• irregularly shaped (J:47700)
• irregularly shaped (J:47700)

skeleton
• sternal defects (J:47700)
• sternal defects (J:47700)
• multiple rib fusions (J:47700)
• multiple rib fusions (J:47700)
• neural arches are unfused dorsally (J:47700)
• unfused arches are splayed apart (J:47700)
• neural arches are unfused dorsally (J:47700)
• unfused arches are splayed apart (J:47700)

Mouse Models of Human Disease
OMIM ID Ref(s)
Neural Tube Defects, Susceptibility To; NTD 182940 J:47700


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory