Phenotypes Associated with This Genotype

Genotype
MGI:3528280

• Allelic Composition: Foxm1^tm1Cle/Foxm1^tm1Cle
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality ( J:95612 )

cardiovascular system

abnormal myocardial fiber morphology ( J:95612 )

• enlarged nuclei containing up to 50-fold more DNA and no binucleate cardiomyocytes are found in homozygotes

• polyploid cardiomyocytes are seen as early as E13 and the size of the nuclei increase from the outer wall inward to the ventricular or atrial cavity

myocardial fiber disarray ( J:95612 )

• the cardiomyocytes are irregularly oriented

thin myocardium ( J:95612 )

• the compact myocardium is thinner than normal

liver/biliary system

abnormal hepatocyte morphology ( J:95612 )

• polyploid hepatocytes with a DNA content 5.5-fold higher than in normal cells are seen starting at E13 when the incidence of these cells is 10-fold higher than in wild-type mice

• the incidence of polyploid hepatocytes decrease with age and is only 3.9 fold higher at E16 and in neonatal homozygotes

muscle

abnormal myocardial fiber morphology ( J:95612 )

• enlarged nuclei containing up to 50-fold more DNA and no binucleate cardiomyocytes are found in homozygotes

• polyploid cardiomyocytes are seen as early as E13 and the size of the nuclei increase from the outer wall inward to the ventricular or atrial cavity

myocardial fiber disarray ( J:95612 )

• the cardiomyocytes are irregularly oriented

thin myocardium ( J:95612 )

• the compact myocardium is thinner than normal

respiratory system

respiratory failure ( J:95612 )

• the few live born homozygotes gasp for air and succumb to apparent suffocation; however, respiratory tract morphology is normal