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Phenotypes Associated with This Genotype
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phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• fat content increased by 80% in 5 month old females
• the mean abdominal fat cell volume was 40% larger than in wild-type

• showed a 15% higher cumulative food intake at 3 months of age but not at 5 months of age

digestive/alimentary system
• small intestinal D-glucose uptake measured in jointly perfused small bowel and liver was increased twofold compared to wild-type

• fat content increased by 80% in 5 month old females
• body water increased by 22% in 5 month old females
• 5 month old mice were bigger than wild-type
• body weight of 3 month old mice, but not of newborns, was increased by 5% compared to wild-type
• by 5 months of age, mice were obese, with a 30% increase in body weight
• in 5 month old females, total body mass was increased by 25%, dry body mass was increased by 22% and fat-free dried mass was increased by 22%

• serum leptin concentration increased twofold in 5 month old mice but showed no difference from wild-type at 3 months of age
• serum cholesterol concentration was increased by 30% compared to wild-type
• increased energy balance (221 kJ) compared to wild-type (109 kJ), with homozygotes retaining 16.3% more energy, however no differences in energy consumption

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:95148

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory