Mouse Genome Informatics
hm
    Rsc1a1tm1Koep/Rsc1a1tm1Koep
B6.129-Rsc1a1tm1Koep
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
adipose tissue
• fat content increased by 80% in 5 month old females
• the mean abdominal fat cell volume was 40% larger than in wild-type

behavior/neurological
• showed a 15% higher cumulative food intake at 3 months of age but not at 5 months of age

digestive/alimentary system
• small intestinal D-glucose uptake measured in jointly perfused small bowel and liver was increased twofold compared to wild-type

growth/size
• fat content increased by 80% in 5 month old females
• body water increased by 22% in 5 month old females
• 5 month old mice were bigger than wild-type
• body weight of 3 month old mice, but not of newborns, was increased by 5% compared to wild-type
• by 5 months of age, mice were obese, with a 30% increase in body weight
• in 5 month old females, total body mass was increased by 25%, dry body mass was increased by 22% and fat-free dried mass was increased by 22%

homeostasis/metabolism
• serum leptin concentration increased twofold in 5 month old mice but showed no difference from wild-type at 3 months of age
• serum cholesterol concentration was increased by 30% compared to wild-type
• increased energy balance (221 kJ) compared to wild-type (109 kJ), with homozygotes retaining 16.3% more energy, however no differences in energy consumption

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:95148