Phenotypes Associated with This Genotype

Genotype
MGI:3526564

• Allelic Composition: Fbxo11^Jf/Fbxo11⁺
• Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

middle ear effusion ( J:85263 )

• middle ear effusion of varying density and composition

behavior/neurological

absent pinna reflex ( J:85263 )

• absent Preyer response in clickbox test

craniofacial

abnormal middle ear ossicle morphology ( J:85263 )

• middle ear bony wall appeared thicker in mutants

short snout ( J:85263 )

• short snout and occipital region, indicating mild craniofacial defects

excessive cerumen ( J:85263 )

• at 11 months of age, the external ear was filled with cerumen

growth/size/body

short snout ( J:85263 )

• short snout and occipital region, indicating mild craniofacial defects

excessive cerumen ( J:85263 )

• at 11 months of age, the external ear was filled with cerumen

decreased body size ( J:85263 )

decreased body weight ( J:85263 )

• heterozygous mice weigh 21% smaller than controls

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:85263 )

N • normal middle ear ossicles and inner ear

N • no significant hair cell degeneration was observed up to 18 months of age

N • no perforations of the tympanic membrane

abnormal middle ear ossicle morphology ( J:85263 )

• middle ear bony wall appeared thicker in mutants

excessive cerumen ( J:85263 )

• at 11 months of age, the external ear was filled with cerumen

abnormal auditory tube morphology ( J:85263 )

• in neonates, the lumen of eustachean tube is smaller with a disrupted epithelial lining; the lumen may contain cellular debris

• the adult eustachean tube was narrower and was bent compared to controls

abnormal tympanic cavity morphology ( J:85263 )

• papillary to polypoid growths in the tympanic cavity

• evidence of inflammatory and fibroblast infiltration

• the middle ear cavity in some neonates had collapsed; in adults, the cavity appeared to be reduced in size

middle ear effusion ( J:85263 )

• middle ear effusion of varying density and composition

tympanic membrane retraction ( J:85263 )

• at 11 months of age, tympanic membrane retraction was evident with calcification in the middle ear

middle ear polyps ( J:85263 )

• papillary to polypoid growths in the tympanic cavity

decreased endocochlear potential ( J:85263 )

• low endocochlear potentials suggesting impaired strial function

deafness ( J:63816 , J:85263 )

• fully penetrant at 4 weeks of age (J:85263)

increased susceptibility to otitis media ( J:85263 )

• chronic proliferative otitis media at moderate severity; included effusion of varying density and composition

immune system

increased susceptibility to otitis media ( J:85263 )

• chronic proliferative otitis media at moderate severity; included effusion of varying density and composition

abnormal cytokine secretion ( J:85263 )

• TNFalpha, IL1beta, and IL8 were all present in middle ear effusions

skeleton

abnormal middle ear ossicle morphology ( J:85263 )

• middle ear bony wall appeared thicker in mutants