Phenotypes Associated with This Genotype

Genotype
MGI:3526549

• Allelic Composition: Mitf^Mi-b/Mitf^Mi-b
• Genetic Background: involves: 101/Rl * C3H/Rl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal Harderian gland pigmentation ( J:37067 )

• pigment granules are absent

absent coat pigmentation ( J:37067 )

• the coat is completely white

abnormal eye pigmentation ( J:37067 )

abnormal choroid pigmentation ( J:37067 )

• no pigmentation is found in the choroid

abnormal retina pigment epithelium morphology ( J:37067 )

• pigment granules are sparse

endocrine/exocrine glands

abnormal Harderian gland pigmentation ( J:37067 )

• pigment granules are absent

vision/eye

abnormal eye pigmentation ( J:37067 )

abnormal choroid pigmentation ( J:37067 )

• no pigmentation is found in the choroid

abnormal ciliary process morphology ( J:37067 )

• fewer than normal ciliary processes

abnormal retina morphology ( J:37067 )

• ciliary bodies have fewer processes than wild-type or heterozygous mice

• pigment greatly reduced in ciliary body and inner layer of iris

• there is a single pigmented epithelial layer rather than normal stratified layer

abnormal retina pigment epithelium morphology ( J:37067 )

• pigment granules are sparse

increased susceptibility to age-related retinal degeneration ( J:37067 )

• reduction in photoreceptor outer segment length begins as early as 19 days of age; inner and outer nuclear layers are normal

• by 3 months of age inner and outer nuclear layers as well as the ganglion layers are reduced significantly

abnormal eye physiology ( J:37067 )

integument

absent coat pigmentation ( J:37067 )

• the coat is completely white