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Phenotypes Associated with This Genotype
Genotype
MGI:3526411
Allelic
Composition
Ambntm1Nid/Ambntm1Nid
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ambntm1Nid mutation (0 available); any Ambn mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Defects in enamel formation of Ambntm1Nid/Ambntm1Nid mice

tumorigenesis
• dental epithelium derived soft tissue tumors in the buccal vestibule of the maxilla were seen in 6 out of 32 mutants with the earliest occurrence at 26 weeks of age (J:94844)
• dental epithelium derived soft tissue tumors in the buccal vestibule of the maxilla were seen in 6 out of 32 mutants with the earliest occurrence at 26 weeks of age (J:94844)

craniofacial
• the space between the tooth and alveolar bone is wider than normal and this space is invaded by calcified tissue (J:94844)
• the space between the tooth and alveolar bone is wider than normal and this space is invaded by calcified tissue (J:94844)
• at P3 ameloblasts begin to detach from the matrix layer and lose cell polarity (J:94844)
• at P7 ameloblast cell polarity is completely lost, proliferation is increased, and the cells accumulate to form a multilayered structure (J:94844)
• at P3 ameloblasts begin to detach from the matrix layer and lose cell polarity (J:94844)
• at P7 ameloblast cell polarity is completely lost, proliferation is increased, and the cells accumulate to form a multilayered structure (J:94844)
• at 3 weeks of age incisors appear chalky white with rounded tips (J:94844)
• at 3 weeks of age incisors appear chalky white with rounded tips (J:94844)
• the occlusal plane of the molar is flattened from attrition after eruption (J:94844)
• the occlusal plane of the molar is flattened from attrition after eruption (J:94844)

skeleton
• the space between the tooth and alveolar bone is wider than normal and this space is invaded by calcified tissue (J:94844)
• the space between the tooth and alveolar bone is wider than normal and this space is invaded by calcified tissue (J:94844)

growth/size/body
• at P3 ameloblasts begin to detach from the matrix layer and lose cell polarity (J:94844)
• at P7 ameloblast cell polarity is completely lost, proliferation is increased, and the cells accumulate to form a multilayered structure (J:94844)
• at P3 ameloblasts begin to detach from the matrix layer and lose cell polarity (J:94844)
• at P7 ameloblast cell polarity is completely lost, proliferation is increased, and the cells accumulate to form a multilayered structure (J:94844)
• at 3 weeks of age incisors appear chalky white with rounded tips (J:94844)
• at 3 weeks of age incisors appear chalky white with rounded tips (J:94844)
• the occlusal plane of the molar is flattened from attrition after eruption (J:94844)
• the occlusal plane of the molar is flattened from attrition after eruption (J:94844)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory