Phenotypes for Tph2 MGI:3525357 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Tph2^Pro447/Tph2^Pro447
Genetic Background	129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tph2^Pro447 mutation (0 available); any Tph2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal serotonin level ( J:94745 )

• increased serotonin levels and increased synthesis of the serotonin precursor 5-hydroxytryptophan (5-HTP) after treatment with m-hydroxybenxylhydrazine in the frontal cortex and striatum, compared to mice in a BALB/cJ background that are homozygous for Tph^Arg447 and have an arginine rather than a proline at amino acid residue 447 of Tph2

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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