Phenotypes for Tph2 MGI:3525355 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Tph2^Arg447/Tph2^Arg447
Genetic Background	DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tph2^Arg447 mutation (0 available); any Tph2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal serotonin level ( J:94745 )

• ~45% decrease in 5-HTP synthesis in the striatum after treatment with m-hydroxybenxylhydrazine, compared to mice in a C57BL/6J background that are homozygous for Tph2^Pro447 and have a proline rather than an arginine at amino acid residue 447 of Tph2

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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