About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3525209
Allelic
Composition
Aipl1tm1Mad/Aipl1tm1Mad
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• an increase in Muller cell reactive gliosis is seen (J:94655)
• an increase in Muller cell reactive gliosis is seen (J:94655)
• the bipolar cells appear expanded or disorganized (J:94655)
• cells counts indicate an increase in the proportion of bipolar cells greater than expected from rod loss alone (22% vs 16% expected from rod loss) (J:94655)
• the bipolar cells appear expanded or disorganized (J:94655)
• cells counts indicate an increase in the proportion of bipolar cells greater than expected from rod loss alone (22% vs 16% expected from rod loss) (J:94655)
• photoreceptor numbers are about 13% of wild-type, exceeding the predicted loss of rods alone (J:94655)
• photoreceptor numbers are about 13% of wild-type, exceeding the predicted loss of rods alone (J:94655)
• the number of cones is reduced (J:94655)
• the number of cones is reduced (J:94655)
• at P12 cone morphology is abnormal (J:94655)
• at P12 cone morphology is abnormal (J:94655)
• a central to peripheral loss of photoreceptors was seen beginning at P12 (J:94655)
• a central to peripheral loss of photoreceptors was seen beginning at P12 (J:94655)
• cell counts indicate a loss of 70% cells in the retina through rod death (J:94655)
• cell counts indicate a loss of 70% cells in the retina through rod death (J:94655)
• at P12 the outer nuclear layer is thinner than normal (J:94655)
• at P12 the outer nuclear layer is thinner than normal (J:94655)
• at P12, ribbon synapse formation in the outer plexiform layer is disrupted (J:94655)
• at P12, ribbon synapse formation in the outer plexiform layer is disrupted (J:94655)
• electroretinography shows less than 1% of normal rod activity with both the a- and b-waves absent (J:94655)
• electroretinography shows less than 1% of normal rod activity with both the a- and b-waves absent (J:94655)

nervous system
• an increase in Muller cell reactive gliosis is seen (J:94655)
• an increase in Muller cell reactive gliosis is seen (J:94655)
• photoreceptor numbers are about 13% of wild-type, exceeding the predicted loss of rods alone (J:94655)
• photoreceptor numbers are about 13% of wild-type, exceeding the predicted loss of rods alone (J:94655)
• the number of cones is reduced (J:94655)
• the number of cones is reduced (J:94655)
• the bipolar cells appear expanded or disorganized (J:94655)
• cells counts indicate an increase in the proportion of bipolar cells greater than expected from rod loss alone (22% vs 16% expected from rod loss) (J:94655)
• the bipolar cells appear expanded or disorganized (J:94655)
• cells counts indicate an increase in the proportion of bipolar cells greater than expected from rod loss alone (22% vs 16% expected from rod loss) (J:94655)
• at P12 cone morphology is abnormal (J:94655)
• at P12 cone morphology is abnormal (J:94655)
• a central to peripheral loss of photoreceptors was seen beginning at P12 (J:94655)
• a central to peripheral loss of photoreceptors was seen beginning at P12 (J:94655)
• cell counts indicate a loss of 70% cells in the retina through rod death (J:94655)
• cell counts indicate a loss of 70% cells in the retina through rod death (J:94655)

Mouse Models of Human Disease
OMIM ID Ref(s)
Leber Congenital Amaurosis 4; LCA4 604393 J:94655


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/26/2016
MGI 6.02
The Jackson Laboratory