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Phenotypes Associated with This Genotype
Genotype
MGI:3524958
Allelic
Composition
Nt5etm1Lft/Nt5etm1Lft
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nt5etm1Lft mutation (3 available); any Nt5e mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• under hypoxic conditions mutants are more lethargic compared to wild-type littermates
• under hypoxic conditions mutants are less compliant compared to wild-type littermates

cardiovascular system
• ischemic preconditioning fails to attenuate infarct size as in wild-type mice
• however, treatment of mice with adenosine or 5' nucleotidase infusion partially-restores cardioprotection offered by ischemic preconditioning
• mice exhibit increased infarct size after 60 minutes of ischemia compared to in similarly-treated wild-type mice
• under hypoxic conditions increased vascular leakage is seen
• under normoxic conditions increased vascular permeability is seen in the lung and colon

homeostasis/metabolism
• ischemic preconditioning fails to attenuate infarct size as in wild-type mice
• however, treatment of mice with adenosine or 5' nucleotidase infusion partially-restores cardioprotection offered by ischemic preconditioning
• mice exhibit increased infarct size after 60 minutes of ischemia compared to in similarly-treated wild-type mice
• under hypoxic conditions increased edema is seen in all organs except the brain
• mice exhibit an attenuated bradycardia response to AMP


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory