behavior/neurological
• under hypoxic conditions mutants are more lethargic compared to wild-type littermates
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• under hypoxic conditions mutants are less compliant compared to wild-type littermates
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cardiovascular system
• ischemic preconditioning fails to attenuate infarct size as in wild-type mice
• however, treatment of mice with adenosine or 5' nucleotidase infusion partially-restores cardioprotection offered by ischemic preconditioning
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• mice exhibit increased infarct size after 60 minutes of ischemia compared to in similarly-treated wild-type mice
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• under hypoxic conditions increased vascular leakage is seen
• under normoxic conditions increased vascular permeability is seen in the lung and colon
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homeostasis/metabolism
• ischemic preconditioning fails to attenuate infarct size as in wild-type mice
• however, treatment of mice with adenosine or 5' nucleotidase infusion partially-restores cardioprotection offered by ischemic preconditioning
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• mice exhibit increased infarct size after 60 minutes of ischemia compared to in similarly-treated wild-type mice
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• mice exhibit an attenuated bradycardia response to AMP
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