Phenotypes Associated with This Genotype

Genotype
MGI:3522661

• Allelic Composition: Foxm1^tm1Rhc/Foxm1^tm1Rhc; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:89472 )

• after diethylnitrosamine (DEN) and phenobarbitol (PB) treatment, no adenomas were observed in liver sections from these mice at 23, 33 and 50 weeks of age in contrast to controls

decreased liver tumor incidence ( J:89472 )

• after diethylnitrosamine (DEN) and phenobarbitol (PB) treatment, no adenomas were observed in liver sections from these mice at 23, 33 and 50 weeks of age in contrast to controls

liver/biliary system

abnormal hepatocyte morphology ( J:81015 , J:89472 )

• hepatocyte hypertrophy and compensatory increase in liver size at 7 days after partial hepatectomy (J:81015)

• hypertrophy of hepatocytes was observed at 23 weeks after diethylnitrosamine (DEN) and phenobarbitol (PB) treatment; hepatocytes exhibited a significant reduction in DNA replication and mitosis (J:89472)

decreased liver tumor incidence ( J:89472 )

• after diethylnitrosamine (DEN) and phenobarbitol (PB) treatment, no adenomas were observed in liver sections from these mice at 23, 33 and 50 weeks of age in contrast to controls

abnormal liver regeneration ( J:81015 )

• after partial hepatectomy, hepatocytes exhibited a significant reduction in DNA replication and mitosis; changes in expression levels of cell cycle proteins were observed

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:89472 )

• after diethylnitrosamine (DEN) and phenobarbitol (PB) treatment, no adenomas were observed in liver sections from these mice at 23, 33 and 50 weeks of age in contrast to controls