Mouse Genome Informatics
hm
    Lama2tm1Eeng/Lama2tm1Eeng
involves: 129S1/Sv * Black Swiss
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
muscle
• 1 month old skeletal muscle showed fiber necrosis and fibrosis, indicating muscle degeneration and developed muscular dystrophy at 2-3 weeks of age
• skeletal muscle was unable to complete regeneration in response to injury
• low incidence of new myotube formation
• newly formed myofibers undergo apoptosis

Mouse Models of Human Disease
OMIM IDRef(s)
Muscular Dystrophy, Congenital Merosin-Deficient, 1A; MDC1A 607855 J:59089