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Phenotypes Associated with This Genotype
Genotype
MGI:3522483
Allelic
Composition
Lama2tm1Eeng/Lama2tm1Eeng
Genetic
Background
involves: 129S1/Sv * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lama2tm1Eeng mutation (1 available); any Lama2 mutation (88 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• 1 month old skeletal muscle showed fiber necrosis and fibrosis, indicating muscle degeneration and developed muscular dystrophy at 2-3 weeks of age
• skeletal muscle was unable to complete regeneration in response to injury
• low incidence of new myotube formation
• newly formed myofibers undergo apoptosis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital merosin-deficient muscular dystrophy 1A DOID:0110636 OMIM:607855
J:59089


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory