Phenotypes Associated with This Genotype

Genotype
MGI:3521933

• Allelic Composition: Mmp13^tm1Smk/Mmp13^tm1Smk
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Distal femoral growth plate from wild-type and Mmp13^tm1Smk/Mmp13^tm1Smk mice

limbs/digits/tail

short femur ( J:94723 )

• in 4 week old mutants the femurs are 8% shorter

skeleton

short femur ( J:94723 )

• in 4 week old mutants the femurs are 8% shorter

abnormal long bone hypertrophic chondrocyte zone ( J:94723 )

• in the proximal tibia the length of the hypertrophic zone is increased by 70% compared to wild-type mice

• the number of hypertrophic chondrocytes and deposition of type X collagen are increased

• the chondrocyte columns are disordered compared to wild-type mice

increased long bone epiphyseal plate size ( J:94723 )

• the length of the growth plates is increased

• in the proximal tibia the growth plate length is increased by 20% and the hypertrophic zone by 70% compared to wild-type mice

increased trabecular bone mass ( J:94723 )

• in 4 week old mutants the trabecular bone mass is increased

delayed bone ossification ( J:94723 )

• formation of primary ossification centers is delayed however by E17.5 ossification centers have formed