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Phenotypes Associated with This Genotype
Genotype
MGI:3521740
Allelic
Composition
Satb1tm1Kos/Satb1tm1Kos
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Satb1tm1Kos mutation (0 available); any Satb1 mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all die by 4 weeks of age
• most mice die between P21 and P26

behavior/neurological
• clasping reflex

growth/size/body
• by 3 days of age, animals were smaller and thinner than controls; progressive increase in difference with age was noted

hematopoietic system
• the few mature T cells underwent apoptosis and failed to proliferate in response to PMA and ionomycin
• composed mostly of cortex, with degenerating cells and a sparse medulla
• progressive reduction with age
• reduced numbers of triple negative immature thymocytes
• mutant thymocytes were mostly blocked at the double-positive stage
• contained shrunken white pulp

immune system
• the few mature T cells underwent apoptosis and failed to proliferate in response to PMA and ionomycin
• composed mostly of cortex, with degenerating cells and a sparse medulla
• progressive reduction with age
• reduced numbers of triple negative immature thymocytes
• mutant thymocytes were mostly blocked at the double-positive stage
• contained shrunken white pulp
• reduced numbers of lymphocytes in lymph node

vision/eye
• incomplete eye opening

endocrine/exocrine glands
• composed mostly of cortex, with degenerating cells and a sparse medulla
• progressive reduction with age

cellular
• the few mature T cells underwent apoptosis and failed to proliferate in response to PMA and ionomycin


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory