Phenotypes Associated with This Genotype

Genotype
MGI:3521707

• Allelic Composition: Il10^tm1Roer/Il10^tm1Roer; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:94537 )

• mutants die by 11th day after T. gondii infection

digestive/alimentary system

abnormal intestinal mucosa morphology ( J:94537 )

• mucosa showed massive hyperplasia and infiltration with inflammatory cells and ectatic lymphatic vessels

crypts of Lieberkuhn abscesses ( J:94537 )

intestinal ulcer ( J:94537 )

• multifocal mucosal necroses resulted in numerous ulcerations

rectal prolapse ( J:94537 )

• all mutants developed prolapse under standard conditions, 9/15 mutants exhibited prolapse under pathogen free conditions

intestinal inflammation ( J:94537 )

• incidence of bowel disease increased with age, reaching 33% at 6 months

• multifocal severe inflammation affected all strata of the colonic wall

peritoneal inflammation ( J:94537 )

endocrine/exocrine glands

crypts of Lieberkuhn abscesses ( J:94537 )

immune system

intestinal inflammation ( J:94537 )

• incidence of bowel disease increased with age, reaching 33% at 6 months

• multifocal severe inflammation affected all strata of the colonic wall

peritoneal inflammation ( J:94537 )

abnormal lymph node morphology ( J:94537 )

• expansion of lymph vessels in the intestine

abnormal hypersensitivity reaction ( J:94537 )

• displayed a twofold increase in ear thickness after contact with allergen 2,4-dinitrochlorobenzene (DNCB) compared to controls, however innate inflammatory response and response to LPS were normal

abnormal cytokine secretion ( J:94537 )

• increased secretion of proinflammatory cytokines, TNF-alpha, IL-6, IL-12 and MCP-1 by stimulated splenocytes

liver inflammation ( J:94537 )

• severe hepatitis seen after T. gondii infection

increased susceptibility to parasitic infection ( J:94537 )

• T. gondii infection resulted in severe hepatitis and death by the 11th day after infection in mutants but not controls

liver/biliary system

liver inflammation ( J:94537 )

• severe hepatitis seen after T. gondii infection