Analysis Tools
mortality/aging
|
• homozygotes are present at E18 but die within the first 15 minutes after birth
|
endocrine/exocrine glands
|
• Rathke's pouch is smaller than normal at E12.5 with no evidence of anterior lobe formation
• sometimes a smaller ventral pouch forms
|
|
• at E12.5
|
|
• gonadotrope cells rarely detected
|
|
• anterior lobes of pituitary are still very small at E14.5
|
respiratory system
|
• more glycogen storage than normal in the lungs
• pulmonary immaturity
|
|
• type II cells in the respiratory epithelium with fewer lamellar bodies (surfactant storage)
(J:19373)
• type II pneumocytes have display less lamellar bodies containing surfactant
(J:79850)
|
|
• lungs fail to inflate at birth but could be inflated by positive airway pressure
• treatment with a combination of dexamethasone and progesterone resulted in mice able to inflate lungs but death still occurred by 45 minutes after birth
|
nervous system
| N |
• motor neuron development is normal
|
|
• Rathke's pouch is smaller than normal at E12.5 with no evidence of anterior lobe formation
• sometimes a smaller ventral pouch forms
|
|
• at E12.5
|
|
• gonadotrope cells rarely detected
|
|
• anterior lobes of pituitary are still very small at E14.5
|
homeostasis/metabolism
|
• hemoglobin oxygen saturation is very low
|
|
• in pituitary
|
|
• in pituitary
|
