Phenotypes Associated with This Genotype

Genotype
MGI:3513190

• Allelic Composition: Neurl1a^tm1Ynj/Neurl1a^tm1Ynj
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:71088 )

N • homozygotes show no differences in ethanol preference relative to wild-type littermates in a two-bottle preference test

N • also, homozygotes show normal performance in several behavioral tests, including the Morris water maze assay for learning and memory

abnormal olfactory discrimination memory ( J:71088 )

• homozygotes exhibit an olfactory discrimination defect, manifested as reduced ability to avoid the odorant isovaleric acid

abnormal locomotor coordination ( J:71088 )

• homozygotes show no obvious defects in motor coordination prior to ethanol injection

• however, mutants are hypersensitive to the effects of ethanol on motor coordination, displaying significantly reduced latencies on the rotarod relative to wild-type

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:71088 )

N • mutants show no differences in blood ethanol concentration or ethanol-induced apoptotic neurodegeneration relative to wild-type

reproductive system

reproductive system phenotype ( J:71088 )

N • in contrast to Neurl^tm1Led mutants, these homozygotes show no apparent deficits in fertility

nervous system

nervous system phenotype ( J:71088 )

N • homozygotes display normal brain size, weight, and morphology relative to wild-type

N • mutants show no histological anomalies in the cerebral cortex, cerebellum, striatum, hippocampus, or dentate gyrus

N • adult neurogenesis in the dentate gyrus and chain migration of neuronal precursors in the rostral migratory stream appears unaffected