Mouse Genome Informatics
hm
    Hoxd13tm1Mrc/Hoxd13tm1Mrc
involves: 129S7/SvEvBrd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
limbs/digits/tail
• homozygotes show a reduction or loss of phalange 2 on digits II and V
• phalangeal bones on other digits are also reduced due to abnormal segmentation
• homozygotes display the formation of an extra postaxial digit ("VI")
• interdigital webbing is sometimes observed
• the d4 carpal bone is never properly formed; instead, it yields an extra carpal bone from which grows the postaxial digit VI
• homozygotes display severe appendicular skeletal defects, including a significant reduction of metacarpal length

skeleton
• homozygotes show a reduction or loss of phalange 2 on digits II and V
• phalangeal bones on other digits are also reduced due to abnormal segmentation
• the d4 carpal bone is never properly formed; instead, it yields an extra carpal bone from which grows the postaxial digit VI
• homozygotes display severe appendicular skeletal defects, including a significant reduction of metacarpal length

endocrine/exocrine glands
N
• ventral prostate appears normal with no reductions in duct tip numbers (J:82540)

Mouse Models of Human Disease
OMIM IDRef(s)
Synpolydactyly 1; SPD1 186000 J:32603