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Phenotypes Associated with This Genotype
Genotype
MGI:3513188
Allelic
Composition
Hoxd13tm1Mrc/Hoxd13tm1Mrc
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd13tm1Mrc mutation (0 available); any Hoxd13 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• homozygotes show a reduction or loss of phalange 2 on digits II and V (J:32603)
• phalangeal bones on other digits are also reduced due to abnormal segmentation (J:32603)
• homozygotes show a reduction or loss of phalange 2 on digits II and V (J:32603)
• phalangeal bones on other digits are also reduced due to abnormal segmentation (J:32603)
• homozygotes display the formation of an extra postaxial digit ("VI") (J:32603)
• homozygotes display the formation of an extra postaxial digit ("VI") (J:32603)
• interdigital webbing is sometimes observed (J:32603)
• interdigital webbing is sometimes observed (J:32603)
• the d4 carpal bone is never properly formed; instead, it yields an extra carpal bone from which grows the postaxial digit VI (J:32603)
• the d4 carpal bone is never properly formed; instead, it yields an extra carpal bone from which grows the postaxial digit VI (J:32603)
• homozygotes display severe appendicular skeletal defects, including a significant reduction of metacarpal length (J:32603)
• homozygotes display severe appendicular skeletal defects, including a significant reduction of metacarpal length (J:32603)

skeleton
• homozygotes show a reduction or loss of phalange 2 on digits II and V (J:32603)
• phalangeal bones on other digits are also reduced due to abnormal segmentation (J:32603)
• homozygotes show a reduction or loss of phalange 2 on digits II and V (J:32603)
• phalangeal bones on other digits are also reduced due to abnormal segmentation (J:32603)
• the d4 carpal bone is never properly formed; instead, it yields an extra carpal bone from which grows the postaxial digit VI (J:32603)
• the d4 carpal bone is never properly formed; instead, it yields an extra carpal bone from which grows the postaxial digit VI (J:32603)
• homozygotes display severe appendicular skeletal defects, including a significant reduction of metacarpal length (J:32603)
• homozygotes display severe appendicular skeletal defects, including a significant reduction of metacarpal length (J:32603)

endocrine/exocrine glands
N
• ventral prostate appears normal with no reductions in duct tip numbers (J:82540)
• ventral prostate appears normal with no reductions in duct tip numbers (J:82540)

Mouse Models of Human Disease
OMIM ID Ref(s)
Synpolydactyly 1; SPD1 186000 J:32603


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory