Phenotypes Associated with This Genotype

Genotype
MGI:3513048

• Allelic Composition: Disp1^icb/Disp1^tm2Amc; Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
• Genetic Background: involves: 129/Sv * C57BL/6J * SWR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality ( J:94270 )

craniofacial

absent parietal bone ( J:94270 )

absent premaxilla ( J:94270 )

abnormal nasal pit morphology ( J:94270 )

• fusion of the nasal pits

abnormal facial morphology ( J:94270 )

• facial midline defects are seen

skeleton

absent parietal bone ( J:94270 )

absent premaxilla ( J:94270 )

nervous system

abnormal neuron differentiation ( J:94270 )

• pMN and pV3 progenitor cells are found at the midline and are reduced in numbers to less than 10% wild-type

absent floor plate ( J:94270 )

embryo

absent floor plate ( J:94270 )

respiratory system

abnormal nasal pit morphology ( J:94270 )

• fusion of the nasal pits

cellular

abnormal neuron differentiation ( J:94270 )

• pMN and pV3 progenitor cells are found at the midline and are reduced in numbers to less than 10% wild-type

growth/size/body

abnormal facial morphology ( J:94270 )

• facial midline defects are seen