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Phenotypes Associated with This Genotype
Genotype
MGI:3511746
Allelic
Composition
Leprtm1Chua/Leprtm1Chua
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1Chua mutation (0 available); any Lepr mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Obesity in Leprtm1Chua/Leprtm1Chua mice (center) and normal weight in Leprtm1.1Chua/Leprtm1.1Chua (left)

behavior/neurological
• males hyperphagic, consume 66.4% more food in a given period

growth/size/body
• visibly obese at weaning
• at 16 weeks of age, males are 91% heavier than normal and females are 140% heavier

homeostasis/metabolism
• males are cold intolerant, suffer severe drops in body temperature when exposed to 0C for up to 80 minutes
• increased serum glucose, by 144% in males and by 75% in females

reproductive system

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:94019


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory