Mouse Genome Informatics
hm
    Leprtm1Chua/Leprtm1Chua
involves: 129 * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Obesity in Leprtm1Chua/Leprtm1Chua mice (center) and normal weight in Leprtm1.1Chua/Leprtm1.1Chua (left)

behavior/neurological
• males hyperphagic, consume 66.4% more food in a given period

growth/size
• visibly obese at weaning
• at 16 weeks of age, males are 91% heavier than normal and females are 140% heavier

homeostasis/metabolism
• males are cold intolerant, suffer severe drops in body temperature when exposed to 0C for up to 80 minutes
• increased serum glucose, by 144% in males and by 75% in females

reproductive system

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:94019