Mouse Genome Informatics
cn
    Irs1tm1Jos/Irs1+
Irs2tm2Mfw/Irs2tm2Mfw
Tg(Ins2-cre)25Mgn/0

involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
endocrine/exocrine glands
• at 6 months beta cell content is decreased 8-fold

growth/size/body

homeostasis/metabolism
• diabetes and progressive severe hyperglycemia are seen starting at 4 weeks of age
• severe, progressive hypoinsulinemia is seen

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:93415