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Phenotypes Associated with This Genotype
Genotype
MGI:3510670
Allelic
Composition
Irs1tm1Jos/Irs1+
Irs2tm2Mfw/Irs2tm2Mfw
Tg(Ins2-cre)25Mgn/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1tm1Jos mutation (0 available); any Irs1 mutation (22 available)
Irs2tm2Mfw mutation (0 available); any Irs2 mutation (10 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• at 6 months beta cell content is decreased 8-fold

growth/size/body

homeostasis/metabolism
• diabetes and progressive severe hyperglycemia are seen starting at 4 weeks of age
• severe, progressive hypoinsulinemia is seen

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:93415


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory