Mouse Genome Informatics
cx
    Col4a3tm1Jhm/Col4a3tm1Jhm
Mmp9tm1Tvu/Mmp9tm1Tvu

involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• double homozygotes exhibit no differences in the progression of glomerulonephritis compared with single Col4a3tm1Jhm mutants, suggesting that MMP9 does not play a major role in the progression of Alport syndrome

renal/urinary system
• double homozygotes exhibit no differences in the progression of glomerulonephritis compared with single Col4a3tm1Jhm mutants, suggesting that MMP9 does not play a major role in the progression of Alport syndrome
• at 8 weeks, double homozygotes exhibit the characteristic splitting and thickening of the glomerular basement membrane observed in the Col4a3tm1Jhm mouse model of Alport syndrome
• thickening of the glomerular basement membrane observed at 8 weeks

Mouse Models of Human Disease
OMIM IDRef(s)
Alport Syndrome, Autosomal Recessive 203780 J:63137