Phenotypes Associated with This Genotype

Genotype
MGI:3505876

• Allelic Composition: C3^tm1Hrc/C3^tm1Hrc; Cr1l^tm1Hmo/Cr1l^tm1Hmo
• Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:59432 )

N • survival of double homozygotes is normal

immune system

abnormal complement pathway ( J:76578 )

• erythrocytes show slightly increased susceptibility to antibody-induced lysis by human, but not by rat, complement compared to wild-type

• antibody-sensitized erythrocytes exhibit increased C3 deposition compared to wild-type cells

• mutant erythrocytes transfused into wild-type mice are more rapidly eliminated than controls indicating increased susceptibility to spontaneous complement attack in vivo, however cells are protected from removal when transfused to C3 deficient mice

reproductive system

reproductive system phenotype ( J:86999 )

N • when mating double homozygous females to Crry^tm1Hmo heterozygous males the expected number of pups of both possible genotypes are seen unlike in the reverse situation when fewer than expected Crry^tm1Hmo homozygous pups are found