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Phenotypes Associated with This Genotype
Genotype
MGI:3505876
Allelic
Composition
C3tm1Hrc/C3tm1Hrc
Cr1ltm1Hmo/Cr1ltm1Hmo
Genetic
Background
involves: 129/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Hrc mutation (2 available); any C3 mutation (10 available)
Cr1ltm1Hmo mutation (0 available); any Cr1l mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• survival of double homozygotes is normal

immune system
• erythrocytes show slightly increased susceptibility to antibody-induced lysis by human, but not by rat, complement compared to wild-type
• antibody-sensitized erythrocytes exhibit increased C3 deposition compared to wild-type cells
• mutant erythrocytes transfused into wild-type mice are more rapidly eliminated than controls indicating increased susceptibility to spontaneous complement attack in vivo, however cells are protected from removal when transfused to C3 deficient mice

reproductive system
N
• when mating double homozygous females to Crrytm1Hmo heterozygous males the expected number of pups of both possible genotypes are seen unlike in the reverse situation when fewer than expected Crrytm1Hmo homozygous pups are found


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory