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Phenotypes Associated with This Genotype
Genotype
MGI:3056813
Allelic
Composition
Cabp4tm1Kpal/Cabp4tm1Kpal
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cabp4tm1Kpal mutation (0 available); any Cabp4 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• rod bipolar dendrites poorly branched and underdeveloped
• occasionally extend into outer nuclear layer
• cone pedicles disorganized and flat
• rod spherules disorganized and flat
• rod outer segments about 15% shorter with lower disk density
• outer nuclear layer missing 1-2 layers of cell bodies
• outer plexiform layer reduced about 51% with a 33% reduction in numbers of photoreceptor terminals and 37% reduction of synaptic ribbons
• changes in outer plexiform layer more pronounced at 6-8 months than at 2 months
• signal transfer to both rod and cone bipolar cells severely reduced
• light adapted ERG a-waves differ by about 20% from normal while b-waves are significantly reduced
• dark adapted ERG a-wave and b-wave components both reduced
• rod photoreceptors exhibit faster responses and less sensitivity

nervous system
• rod bipolar dendrites poorly branched and underdeveloped
• occasionally extend into outer nuclear layer
• cone pedicles disorganized and flat
• rod spherules disorganized and flat
• rod outer segments about 15% shorter with lower disk density


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory