Analysis Tools
mortality/aging
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• partial lethality is seen after E10.5 when chimeras are crossed to ICR females
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cardiovascular system
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• the diameter of the dorsal aorta is reduced in 60% of embryos at E9.0 and in 90% of embryos at E9.5 and E10.5
• the location and extent of constriction varied, but was primarily observed rostrally between the cardiac level and the intersections with the branchial arch arteries, but some embryos exhibited longer zones of constriction extending caudally
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• the umbilical artery is reduced in size
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• the placental blood vessels are reduced in size
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• the anterior and posterior cardinal veins were reduced in caliber and disorganized in embryos with severely constricted dorsal aortas
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• the major vitelline arteries and arterial branching on the yolk sac are reduced in all embryos
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• the pericardial space is enlarged in more severely affected embryos at E10.5
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• all embryos show reduced vitelline circulation
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embryo
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• the umbilical artery is reduced in size
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• the placental blood vessels are reduced in size
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• the major vitelline arteries and arterial branching on the yolk sac are reduced in all embryos
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• a progressive developmental delay is seen in some embryos starting at E8.5
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growth/size/body
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• a progressive developmental delay is seen in some embryos starting at E8.5
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