Phenotypes for Dll4 MGI:3056405 MGI Mouse

embryonic lethality during organogenesis, complete penetrance ( J:93157 )

• by E10.5 no viable embryos are found

• the major arteries are abnormal

• endothelial cells accumulate at the apical portion of the intersomitic vessels and the dorsal vessel in this region is dilated

• arterial atrophy is seen by E9.5

abnormal vascular development ( J:93157 )

• many arteries no longer develop as arteries but show markers of a venous fate

abnormal dorsal aorta morphology ( J:93157 )

• the diameter of the dorsal aorta is reduced by E8.75

• by E9.5 the dorsal aorta is severely reduced or absent

abnormal vascular regression ( J:93157 )

• the vasculature in the head remains a simple plexus of disorganized and fused vessels

abnormal vascular branching morphogenesis ( J:93157 )

• branching morphogenesis is reduced

abnormal anterior cardinal vein morphology ( J:93157 )

• in some embryos the dorsal aorta and anterior cardinal vein are fused at the level of the sinus venosus

abnormal vein morphology ( J:93157 )

• at E8.75 the anterior cardinal vein is reduced in caliber and has ectopic branches, at E9.0 the reduction in size is more severe, and by E9.5 a distinct anterior cardinal vein is absent

abnormal sinus venosus morphology ( J:93157 )

• at E8.75 the sinus venosus is smaller than normal and this reduction is more severe at E 9.5

abnormal heart atrium morphology ( J:93157 )

• the atria are reduced is size

abnormal heart ventricle morphology ( J:93157 )

• the ventricles are reduced in size

trabecula carnea hypoplasia ( J:93157 )

pericardial edema ( J:93157 )

• severe pericardial swelling is seen at E9.0

embryonic growth retardation ( J:93157 )

• severe growth retardation is seen by E9.5

abnormal vitelline vascular remodeling ( J:93157 )

• the major vitelline artery is severely reduced

• the vascular plexus is not remodeled into a more mature vascular network