Mouse Genome Informatics
ot
    Rs1tm1Sie/Y
involves: 129S/SvEv * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
vision/eye
• innermost "RGC" layer with increased number of cells and some mislocated (J:93040)
• no progressive degeneration through six months of age (J:93040)
• photoreceptor number in the outer nuclear layer slightly reduced (J:93040)
• irregular laminations in the inner nuclear layer and outer plexiform layer (J:93040)
• structural gaps in the inner nuclear layer (J:93040)
• clumps of photoreceptor nuclei mislocated to the inner and outer segments (J:93040)
• diminished dark-adapted ERG b-wave (J:93040)
• Irregular ERG with higher intensity stimulation (J:93040)

Mouse Models of Human Disease
OMIM IDRef(s)
Retinoschisis 1, X-Linked, Juvenile; RS1 312700 J:93040