Phenotypes Associated with This Genotype

Genotype
MGI:3056194

• Allelic Composition: Hdac5^tm1Eno/Hdac5^tm1Eno; Hdac9^tm1Eno/Hdac9^tm1Eno
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:93021 )

• double homozygous embryos begin to die around E15.5 with only about 12% of double homozygotes surviving to adulthood

cardiovascular system

ventricular septal defect ( J:93021 )

• at E15.5 ventricular septal defects were seen in 77% of double homozygous embryos often associated with hemorrhages

cardiac hypertrophy ( J:93021 )

• 1 month old mutant heart to body weight ratios are increased and markers of cardiac hypertrophy are upregulated

thin ventricular wall ( J:93021 )

• at E15.5 thin ventricular walls were seen in 20% of double homozygous embryos often associated with hemorrhages

hemorrhage ( J:93021 )

• hemorrhages are seen throughout the body of some mutant embryos at E15.5

growth/size/body

cardiac hypertrophy ( J:93021 )

• 1 month old mutant heart to body weight ratios are increased and markers of cardiac hypertrophy are upregulated

postnatal growth retardation ( J:93021 )

• severe growth retardation is seen with surviving adults weighing 1/3 as much as wild-type mice

muscle

abnormal skeletal muscle fiber type ratio ( J:127416 )

• soleus muscles show an increase in the percentage of slow myofibers