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Phenotypes Associated with This Genotype
Genotype
MGI:3055667
Allelic
Composition
Dysfprmd/Dysfprmd
Genetic
Background
A/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dysfprmd mutation (5 available); any Dysf mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• hind-limb clasping develops after 8 months of age (J:92838)
• inability to spread legs when suspended by their tails after 8 months of age (J:92838)
• hind-limb clasping develops after 8 months of age (J:92838)
• inability to spread legs when suspended by their tails after 8 months of age (J:92838)

muscle
• perivascular infiltrates and inflammation seen by 8 months of age (J:92838)
• eventually, active myopathy was seen in all skeletal muscles (J:92838)
• perivascular infiltrates and inflammation seen by 8 months of age (J:92838)
• eventually, active myopathy was seen in all skeletal muscles (J:92838)
• abnormalities primarily in proximal muscles at early ages (J:92838)
• hypertrophic fibers, fiber splitting and fat replacement also seen (J:92838)
• abnormalities primarily in proximal muscles at early ages (J:92838)
• hypertrophic fibers, fiber splitting and fat replacement also seen (J:92838)
• fibers with scattered degenerating and regenerating fibers by 4-5 months of age (J:92838)
• fibers with scattered degenerating and regenerating fibers by 4-5 months of age (J:92838)
• increased numbers of necrotic and regenerating fibers with time (J:92838)
• increased numbers of necrotic and regenerating fibers with time (J:92838)
• endomysial fibrosis at later stages (J:92838)
• endomysial fibrosis at later stages (J:92838)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory