About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3055667
Allelic
Composition
Dysfprmd/Dysfprmd
Genetic
Background
A/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dysfprmd mutation (5 available); any Dysf mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• hind-limb clasping develops after 8 months of age
• inability to spread legs when suspended by their tails after 8 months of age

muscle
• perivascular infiltrates and inflammation seen by 8 months of age
• eventually, active myopathy was seen in all skeletal muscles
• abnormalities primarily in proximal muscles at early ages
• hypertrophic fibers, fiber splitting and fat replacement also seen
• fibers with scattered degenerating and regenerating fibers by 4-5 months of age
• increased numbers of necrotic and regenerating fibers with time
• endomysial fibrosis at later stages


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory