About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3055584
Allelic
Composition
Bbs1Gt1Nk/Bbs1Gt1Nk
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bbs1Gt1Nk mutation (1 available); any Bbs1 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 40-50% embryonic lethality is seen at E10.5 (J:92950)
• 40-50% embryonic lethality is seen at E10.5 (J:92950)

growth/size/body
• olfactory cilia lack stable microtubules and the ciliary layer is thinner compared to wild-type (J:92950)
• olfactory cilia lack stable microtubules and the ciliary layer is thinner compared to wild-type (J:92950)
• the apical dendrites are distorted rather than projecting straight to the surface as in wild-type mice (J:92950)
• the apical dendrites are distorted rather than projecting straight to the surface as in wild-type mice (J:92950)
• all homozygotes are runts at birth, however no mutants display polydactyly, situs inversus, or renal or liver abnormalities unlike humans with BBS mutations (J:92950)
• all homozygotes are runts at birth, however no mutants display polydactyly, situs inversus, or renal or liver abnormalities unlike humans with BBS mutations (J:92950)
• by 10 weeks of age 10% of homozygotes are obese (J:92950)
• by 10 weeks of age 10% of homozygotes are obese (J:92950)

taste/olfaction
• olfactory cilia lack stable microtubules and the ciliary layer is thinner compared to wild-type (J:92950)
• olfactory cilia lack stable microtubules and the ciliary layer is thinner compared to wild-type (J:92950)
• the apical dendrites are distorted rather than projecting straight to the surface as in wild-type mice (J:92950)
• the apical dendrites are distorted rather than projecting straight to the surface as in wild-type mice (J:92950)

vision/eye
• 30% of homozygotes develop retinal degeneration (J:92950)
• 30% of homozygotes develop retinal degeneration (J:92950)

nervous system
• the apical dendrites are distorted rather than projecting straight to the surface as in wild-type mice (J:92950)
• the apical dendrites are distorted rather than projecting straight to the surface as in wild-type mice (J:92950)

respiratory system
• olfactory cilia lack stable microtubules and the ciliary layer is thinner compared to wild-type (J:92950)
• olfactory cilia lack stable microtubules and the ciliary layer is thinner compared to wild-type (J:92950)
• the apical dendrites are distorted rather than projecting straight to the surface as in wild-type mice (J:92950)
• the apical dendrites are distorted rather than projecting straight to the surface as in wild-type mice (J:92950)

craniofacial
• olfactory cilia lack stable microtubules and the ciliary layer is thinner compared to wild-type (J:92950)
• olfactory cilia lack stable microtubules and the ciliary layer is thinner compared to wild-type (J:92950)
• the apical dendrites are distorted rather than projecting straight to the surface as in wild-type mice (J:92950)
• the apical dendrites are distorted rather than projecting straight to the surface as in wild-type mice (J:92950)

Mouse Models of Human Disease
OMIM ID Ref(s)
Bardet-Biedl Syndrome 1; BBS1 209900 J:92950
Obesity 601665 J:92950


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory