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Phenotypes Associated with This Genotype
Genotype
MGI:3055578
Allelic
Composition
Dysftm1Meho/Dysftm1Meho
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dysftm1Meho mutation (0 available); any Dysf mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• hind-limb clasping develops after 8 months of age
• inability to spread legs when suspended by their tails after 8 months of age

muscle
• perivascular infiltrates and inflammation seen by 8 months of age
• fibers with scattered degenerating and regenerating fibers by 2 months of age
• abnormalities primarily in proximal muscles at early ages
• hypertrophic fibers, fiber splitting and fat replacement are seen at 5 months of age
• nuclei are centrally placed
• by 5 months of age, increased numbers of necrotic and regenerating fibers are present
• endomysial fibrosis at 8 months of age


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory