Phenotypes for Tnf Tnfaip3 MGI:3055288 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Tnf^tm1Gkl/Tnf^tm1Gkl Tnfaip3^tm1Ama/Tnfaip3^tm1Ama
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfaip3^tm1Ama mutation (0 available); any Tnfaip3 mutation (43 available)
Tnf^tm1Gkl mutation (6 available); any Tnf mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:92694 )

growth/size/body

cachexia ( J:92694 )

immune system

abnormal cytokine secretion ( J:92694 )

• bone marrow derived macrophages produce more IL-6 and nitric oxide in response to LPS treatment compared to Tnfaip1^tm1Ama heterozygous Tnf^tm1Gkl homozygous macrophages

abnormal inflammatory response ( J:92694 )

• the absolute number and percentage of myeloid cells is increased in multiple tissues

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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