mortality/aging
• most homozygotes die around E12.5
|
cardiovascular system
• development of two complete hearts apparent by E8.5
• both structurally normal
|
cardia bifida
(
J:92817
)
• no bilateral heart tube fusion although looping morphogenesis was normal
|
• two hearts were located bilaterally
|
• normal heart rate for both hearts but heart beats were asynchronous
|
digestive/alimentary system
• failure of the foregut to close before E11.5
|
• failure of the foregut to divide into trachea and esophagus
• lungs and liver do develop however
|
respiratory system
• failure of the foregut to divide into trachea and esophagus
• lungs and liver do develop however
|