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Phenotypes Associated with This Genotype
Genotype
MGI:3054803
Allelic
Composition
Aipl1tm1Tili/Aipl1tm1Tili
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aipl1tm1Tili mutation (0 available); any Aipl1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Age-dependent retinal degeneration in Aipl1tm1Tili/Aipl1tm1Tili mice

vision/eye
• disorganization of the outer segments of the retina and increased pycnotic nuclei are seen by 3 months
• by 8 months, more than half of the photoreceptors are lost
• in 5-6 week old mutants an increase in mean latency and a 31% decrease in the geometric mean of phototransduction is seen in an electroretinogram
• a delayed onset and slower initial rate of rise of the single photon response is seen in isolated rods

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Leber congenital amaurosis 4 DOID:0110332 OMIM:604393
J:92601


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/11/2017
MGI 6.08
The Jackson Laboratory