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Phenotypes Associated with This Genotype
Genotype
MGI:3054803
Allelic
Composition
Aipl1tm1Tili/Aipl1tm1Tili
Genetic
Background
involves: 129S4/SvJae * C57BL/6
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype

Age-dependent retinal degeneration in Aipl1tm1Tili/Aipl1tm1Tili mice

vision/eye
• disorganization of the outer segments of the retina and increased pycnotic nuclei are seen by 3 months (J:92601)
• by 8 months, more than half of the photoreceptors are lost (J:92601)
• disorganization of the outer segments of the retina and increased pycnotic nuclei are seen by 3 months (J:92601)
• by 8 months, more than half of the photoreceptors are lost (J:92601)
• in 5-6 week old mutants an increase in mean latency and a 31% decrease in the geometric mean of phototransduction is seen in an electroretinogram (J:92601)
• a delayed onset and slower initial rate of rise of the single photon response is seen in isolated rods (J:92601)
• in 5-6 week old mutants an increase in mean latency and a 31% decrease in the geometric mean of phototransduction is seen in an electroretinogram (J:92601)
• a delayed onset and slower initial rate of rise of the single photon response is seen in isolated rods (J:92601)

Mouse Models of Human Disease
OMIM ID Ref(s)
Leber Congenital Amaurosis 4; LCA4 604393 J:92601


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory