Mouse Genome Informatics
hm
    Pdcd1tm1Hon/Pdcd1tm1Hon
B6.129S2-Pdcd1tm1Hon
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• increased layers of synovial tissues in foot joints at 6 months of age
• arthritic lesions more pronounced at 14 months of age
• mild proliferative glomerulonephritis at 6 months age
• less than 50% of glomeruli affected
• by 14 months, 50% of mice with a lupus-like glomerulonephritis
• only about 80% of mice show long term MHC class II mismatch allograft survival (Bm12 into B6) compared to about 100% survival in wild-type mice
• however, survival time of MHC class I mismatch allografts is the same as wild-type controls

renal/urinary system
• mild proliferative glomerulonephritis at 6 months age
• less than 50% of glomeruli affected
• by 14 months, 50% of mice with a lupus-like glomerulonephritis

skeleton
• increased layers of synovial tissues in foot joints at 6 months of age
• arthritic lesions more pronounced at 14 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
Systemic Lupus Erythematosus, Susceptibility to, 2; SLEB2 605218 J:78802