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Phenotypes Associated with This Genotype
Genotype
MGI:3054644
Allelic
Composition
Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic
Background
B6.129S2-Pdcd1tm1Hon
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased layers of synovial tissues in foot joints at 6 months of age
• arthritic lesions more pronounced at 14 months of age
• mild proliferative glomerulonephritis at 6 months age
• less than 50% of glomeruli affected
• by 14 months, 50% of mice with a lupus-like glomerulonephritis
• only about 80% of mice show long term MHC class II mismatch allograft survival (Bm12 into B6) compared to about 100% survival in wild-type mice
• however, survival time of MHC class I mismatch allografts is the same as wild-type controls

renal/urinary system
• mild proliferative glomerulonephritis at 6 months age
• less than 50% of glomeruli affected
• by 14 months, 50% of mice with a lupus-like glomerulonephritis

skeleton
• increased layers of synovial tissues in foot joints at 6 months of age
• arthritic lesions more pronounced at 14 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Systemic Lupus Erythematosus, Susceptibility to, 2; SLEB2 605218 J:78802


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory