Phenotypes for Scn9a Scn10a MGI:3053686 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Scn10a^tm2(cre)Jwo/Scn10a⁺ Scn9a^tm1Jwo/Scn9a^tm1Jwo
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)
Scn9a^tm1Jwo mutation (0 available); any Scn9a mutation (120 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal nociception after inflammation ( J:92442 )

• inflammation does not result in thermal or mechanical hyperalgesia in mutants unlike in wild-type mice

abnormal pain threshold ( J:92442 )

• homozygotes are significantly less sensitive to noxious mechanical stimulation compared to wild-type mice

increased thermal nociceptive threshold ( J:92442 )

• mutants are about 20% less sensitive to noxious thermal stimulation compared to wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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