Phenotypes Associated with This Genotype

Genotype
MGI:3052916

• Allelic Composition: Tbxas1^tm1Swl/Tbxas1^tm1Swl
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased platelet aggregation ( J:90922 )

• platelet aggregation in response to arachidonic acid is almost completely absent

immune system

decreased inflammatory response ( J:90922 )

• homozygous mutants do not develop cardiac arrest 2 minutes after intravenous arachidonic acid infusion unlike wild-type mice

homeostasis/metabolism

decreased platelet aggregation ( J:90922 )

• platelet aggregation in response to arachidonic acid is almost completely absent

increased bleeding time ( J:90922 )

• bleeding time is significantly longer compared to wild-type mice