Phenotypes Associated with This Genotype

Genotype
MGI:3052357

• Allelic Composition: Dusp10^tm1Flv/Dusp10^tm1Flv
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased activated T cell number ( J:92104 )

• enhanced APC priming in response to LPS stimulation

abnormal adaptive immunity ( J:92104 )

decreased T cell proliferation ( J:92104 )

• in response to antigen

increased susceptibility to type I hypersensitivity reaction ( J:92104 )

• fatal response to secondary LCMV challenge

abnormal cytokine secretion ( J:92104 )

increased interferon-gamma secretion ( J:92104 )

• antigen stimulation of Th1 and Th2 cells produced increased levels of IFNG

• anti-CD3 stimulated Th1 and Th2 cells produced increased levels of IFNG

abnormal interleukin secretion ( J:92104 )

• anti-CD3 stimulated Th1 and Th2 cells produced increased levels of IL4

• LPS stimulated antigen presenting cells produce increased levels of IL2

• macrophages produced increased levels of IL6 in response to LPS stimulation or bacterial infection

increased tumor necrosis factor secretion ( J:92104 )

• antigen stimulation of Th1 and Th2 cells produced increased levels of TNFA

• macrophages produced increased levels of TNFA in response to LPS stimulation or bacterial infection

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:92104 )

• decreased incidence and severity of disease in response to EAE induction

hematopoietic system

decreased T cell proliferation ( J:92104 )

• in response to antigen

increased activated T cell number ( J:92104 )

• enhanced APC priming in response to LPS stimulation

cellular

decreased T cell proliferation ( J:92104 )

• in response to antigen