Phenotypes Associated with This Genotype

Genotype
MGI:3052355

• Allelic Composition: Pias1^tm1Kes/Pias1^tm1Kes
• Genetic Background: involves: 129S/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:92167 )

• more mutants die when exposed to Listeria monocytogenes compared to wild-type mice

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:92167 )

• the antiviral response is enhanced and fewer mutants die after exposure to vesicular stomatitis virus compared to wild-type mice

perinatal lethality, incomplete penetrance ( J:92167 )

• a normal mendelian ratio is seen at E17.5 however at P1 fewer than expected homozygotes are found

• surviving homozygotes are fertile and do not display a reduced life span

growth/size/body

decreased body size ( J:92167 )

• homozygous males and females are about 40% and 20-30% smaller respectively

immune system

increased susceptibility to endotoxin shock ( J:92167 )

• homozygotes are hypersensitive to LPS-induced endotoxin shock

increased susceptibility to bacterial infection induced morbidity/mortality ( J:92167 )

• more mutants die when exposed to Listeria monocytogenes compared to wild-type mice

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:92167 )

• the antiviral response is enhanced and fewer mutants die after exposure to vesicular stomatitis virus compared to wild-type mice