Phenotypes Associated with This Genotype

Genotype
MGI:3052338

• Allelic Composition: Psen1^tm1Shs/Psen1^tm1Shs
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:91975 )

• no living homozygous pups are found

cardiovascular system

intracranial hemorrhage ( J:91975 )

• intracranial hemorrhages are seen late in gestation

embryo

decreased embryo size ( J:91975 )

• homozygous embryos are smaller than normal

growth/size/body

decreased embryo size ( J:91975 )

• homozygous embryos are smaller than normal

limbs/digits/tail

short tail ( J:91975 )

• embryos have short tails

nervous system

intracranial hemorrhage ( J:91975 )

• intracranial hemorrhages are seen late in gestation

abnormal neuron differentiation ( J:91975 )

• increased proliferation of neuronal precursors is seen in the neocortical primordium at E14 - E16

• neuronal cell cycle length is increased probably as a result of an increase in S-phase length

premature neuronal precursor differentiation ( J:91975 )

• premature differentiation neuronal precursors is seen in the neocortical primordium at E14 - E16

abnormal neuronal migration ( J:91975 )

• increased migration of immature neurons is seen in the neocortical primordium at E14 - E16

abnormal neuronal precursor proliferation ( J:91975 )

• increased proliferation of neuronal precursors is seen in the neocortical primordium at E14 - E16

abnormal stratification in cerebral cortex ( J:91975 )

• cortical stratification is altered

increased neuronal precursor cell number ( J:91975 )

cellular

abnormal neuron differentiation ( J:91975 )

• increased proliferation of neuronal precursors is seen in the neocortical primordium at E14 - E16

• neuronal cell cycle length is increased probably as a result of an increase in S-phase length

premature neuronal precursor differentiation ( J:91975 )

• premature differentiation neuronal precursors is seen in the neocortical primordium at E14 - E16

abnormal neuronal migration ( J:91975 )

• increased migration of immature neurons is seen in the neocortical primordium at E14 - E16

abnormal neuronal precursor proliferation ( J:91975 )

• increased proliferation of neuronal precursors is seen in the neocortical primordium at E14 - E16