About   Help   FAQ
Phenotypes Associated with This Genotype
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc29a1tm1Msg mutation (1 available); any Slc29a1 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• voluntarily consume more ethanol compared to wild-type littermates
• increase in consumption is not related to a change in taste preference as no difference in preference for saccharin or quinine is seen
• administration of an A1 receptor agonist reduces alcohol consumption and preference in mutant but not wild-type mice
• the severity of ethanol-induced motor incoordination and loss of righting reflex is reduced compared to wild-type controls
• however, blood ethanol concentrations do not differ from wild-type

nervous system
• incubation of brain slices with an A1 receptor antagonist (1,3-dipropyl-8-cyclopentylxanthine) fails to increase evoked EPSC amplitude unlike in wild-type littermate brain slices
• the frequency of spontaneous EPSCs in the striatum is increased 2.5-fold compared to wild-type littermates
• the increase in frequncy is associated with a slight but significant increase in amplitude


Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
alcohol dependence DOID:0050741 OMIM:103780

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.12
The Jackson Laboratory