Phenotypes Associated with This Genotype

Genotype
MGI:3051903

• Allelic Composition: Socs1^tm1Jni/Socs1^tm1Jni
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:57475 )

• homozygotes die by 3 weeks of age

hematopoietic system

decreased thymocyte number ( J:57475 )

• numbers begin to decrease within a few days of birth

abnormal T cell differentiation ( J:57475 )

• by day 10 an almost exclusively single positive population of cells

• significant numbers of CD4+ and CD8+ cells in bone marrow

• peripheral splenic T cells are morphologically large blasting cells

• T-cells proliferate in response to Il-2 alone

decreased B cell number ( J:57475 )

• dramatically reduced numbers of B cells in the spleen

immune system

decreased thymocyte number ( J:57475 )

• numbers begin to decrease within a few days of birth

abnormal T cell differentiation ( J:57475 )

• by day 10 an almost exclusively single positive population of cells

• significant numbers of CD4+ and CD8+ cells in bone marrow

• peripheral splenic T cells are morphologically large blasting cells

• T-cells proliferate in response to Il-2 alone

decreased B cell number ( J:57475 )

• dramatically reduced numbers of B cells in the spleen

abnormal cytokine secretion ( J:57475 )

• IFN gamma levels in serum are increased

endocrine/exocrine glands

decreased thymocyte number ( J:57475 )

• numbers begin to decrease within a few days of birth