About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3050786
Allelic
Composition
Msx1tm1Rilm/Msx1tm1Rilm
Msx2tm1Rilm/Msx2tm1Rilm
Genetic
Background
involves: 129S4/SvJae * BALB/c * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Rilm mutation (1 available); any Msx1 mutation (8 available)
Msx2tm1Rilm mutation (1 available); any Msx2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• only sparse mesenchymal cells expression alpha-SMA are found in atrioventricular cushions indicating a defect in EMT (J:139946)
• only sparse mesenchymal cells expression alpha-SMA are found in atrioventricular cushions indicating a defect in EMT (J:139946)
• deformed at E14.5 and E16.5 (J:139946)
• deformed at E14.5 and E16.5 (J:139946)
• hypoplastic (J:139946)
• hypoplastic (J:139946)
• at E14.5 and E16.5 (J:139946)
• at E14.5 and E16.5 (J:139946)
• deformed valves at E14.5 and E16.5 (J:139946)
• shorter but thicker valves indicating a failure of valve outgrowth and remodeling (J:139946)
• deformed valves at E14.5 and E16.5 (J:139946)
• shorter but thicker valves indicating a failure of valve outgrowth and remodeling (J:139946)

craniofacial
• double mutant embryos that survive until late gestation display no calvarial ossification; in contrast, the chondrocranium is preserved (J:61509)
• double mutant embryos that survive until late gestation display no calvarial ossification; in contrast, the chondrocranium is preserved (J:61509)
• in double homozygotes, tooth development arrests at the lamina or early bud stages, i.e. earlier than the bud stage arrest observed in Msx1tm1Rilm mutants (J:61509)
• in double homozygotes, tooth development arrests at the lamina or early bud stages, i.e. earlier than the bud stage arrest observed in Msx1tm1Rilm mutants (J:61509)

endocrine/exocrine glands
• all male and female double homozygotes show a failure of mammary epithelial invagination, resulting in subsequent regression (J:61509)
• all male and female double homozygotes show a failure of mammary epithelial invagination, resulting in subsequent regression (J:61509)

skeleton
• double mutant embryos that survive until late gestation display no calvarial ossification; in contrast, the chondrocranium is preserved (J:61509)
• double mutant embryos that survive until late gestation display no calvarial ossification; in contrast, the chondrocranium is preserved (J:61509)

integument
• all male and female double homozygotes show a failure of mammary epithelial invagination, resulting in subsequent regression (J:61509)
• all male and female double homozygotes show a failure of mammary epithelial invagination, resulting in subsequent regression (J:61509)
• at E18.5, the number of hair follicles in double-mutant dorsal back skin is reduced to ~1/3 that of wild-type (J:61509)
• at E18.5, the number of hair follicles in double-mutant dorsal back skin is reduced to ~1/3 that of wild-type (J:61509)

growth/size/body
• in double homozygotes, tooth development arrests at the lamina or early bud stages, i.e. earlier than the bud stage arrest observed in Msx1tm1Rilm mutants (J:61509)
• in double homozygotes, tooth development arrests at the lamina or early bud stages, i.e. earlier than the bud stage arrest observed in Msx1tm1Rilm mutants (J:61509)

Mouse Models of Human Disease
OMIM ID Ref(s)
Tooth Agenesis, Selective, 1; STHAG1 106600 J:61509


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory