Mouse Genome Informatics
cx
    Msx1tm1Rilm/Msx1tm1Rilm
Msx2tm1Rilm/Msx2tm1Rilm

involves: 129S4/SvJae * BALB/c * CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
craniofacial
• double mutant embryos that survive until late gestation display no calvarial ossification; in contrast, the chondrocranium is preserved
• in double homozygotes, tooth development arrests at the lamina or early bud stages, i.e. earlier than the bud stage arrest observed in Msx1tm1Rilm mutants

endocrine/exocrine glands
• all male and female double homozygotes show a failure of mammary epithelial invagination, resulting in subsequent regression

skeleton
• double mutant embryos that survive until late gestation display no calvarial ossification; in contrast, the chondrocranium is preserved

integument
• all male and female double homozygotes show a failure of mammary epithelial invagination, resulting in subsequent regression
• at E18.5, the number of hair follicles in double-mutant dorsal back skin is reduced to ~1/3 that of wild-type

Mouse Models of Human Disease
OMIM IDRef(s)
Tooth Agenesis, Selective, 1; STHAG1 106600 J:61509