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Phenotypes Associated with This Genotype
Genotype
MGI:3050555
Allelic
Composition
Prkntm1Tmd/Prkntm1Tmd
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkntm1Tmd mutation (0 available); any Prkn mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Decrease in tyrosine hydroxylase (TH) containing neurons in the locus coeruleus (LC) of Prkntm1Tmd/Prkntm1Tmd mice

behavior/neurological
• the acoustic startle reflex is significantly decreased

nervous system
• norepinephrine levels are reduced in the locus coeruleus, olfactory bulb, and spinal cord but not in the cerebral cortex, brainstem, prefrontal cortex, hippocampus, diencephalon, and cerebellum of homozygous mutants compared to wild-type mice
• a reduction in dopamine neuron number is seen in the locus coeruleus by 2 months of age

homeostasis/metabolism
• norepinephrine levels are reduced in the locus coeruleus, olfactory bulb, and spinal cord but not in the cerebral cortex, brainstem, prefrontal cortex, hippocampus, diencephalon, and cerebellum of homozygous mutants compared to wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease 2 DOID:0060368 OMIM:600116
J:91487


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory