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Phenotypes Associated with This Genotype
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm1Mae mutation (1 available); any Pparg mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• interscapular brown adipose tissue and gonadal fat mass are reduced to about 80% and 70% wild-type, respectively, however the inguinal fat pad and pectoral subcutaneous fat pad are each increased to about 140% wild-type
• the overall ratio of intra-abdominal to extra-abdominal fat weight is reduced to 63% wild-type
• the size of adipocytes is abnormally uniform with fewer small cells found
• gonadal fat mass is reduced to about 70% wild-type as a result of a decrease in cell numbers
• the inguinal fat pad is increased to about 140% wild-type

cardiovascular system
• blood pressure is increased about 8 mmHg in both male and female mutants

endocrine/exocrine glands
• islet area and endocrine mass are significantly increased in mutants fed a high fat diet

• glucose tolerance is improved and insulin sensitivity is normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
NOT familial partial lipodystrophy DOID:0050440 OMIM:PS151660

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory