Analysis Tools
vision/eye
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• double mutant newborns display accelerated lens degeneration relative to Hspg2tm1Soin mice, as well as more severe lens defects relative to single mutant mice
• the first signs of abnormal development are already apparent in neonates in that leakages of cells are detected in the anterior region of the lens; in Hspg2tm1Soin mice, leakages are observed in a more posterior region and are less severe
• in double mutant lenses, epithelial cells migrate focally outwards, proliferate and remain external for several weeks
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