Phenotypes for Gata2 MGI:3047301 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gata2^tm1Mym/Gata2^tm1Mym
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata2^tm1Mym mutation (1 available); any Gata2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:84836 , J:106045 )

• die between E9.5 and E11.5 (J:84836)

hematopoietic system

abnormal blood cell morphology/development ( J:84836 )

• at E9.5, but not in older embryos, increased numbers of CD45+ cells and decreased numbers of CD45^low cells are seen in the yolk sac suggesting depletion of the precursor cells

abnormal definitive hematopoiesis ( J:106045 )

• at E10, severely reduced numbers of hematopoietic cells are present

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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