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Phenotypes Associated with This Genotype
Genotype
MGI:3047138
Allelic
Composition
Capn3Gt(OST141731)Lex/Capn3Gt(OST141731)Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn3Gt(OST141731)Lex mutation (1 available); any Capn3 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• young mutant males are smaller than wild-type

muscle
• the A-bands of mutant sarcomeres are misaligned resulting in a ragged appearance
• abundant and disorganized mitochondria and lobulated fibers are seen
• rare and small foci of necrosis and regeneration accompanied by inflammatory cells are seen
• the slow fiber area is reduced by about 15%
• rare and small foci of necrosis and regeneration accompanied by inflammatory cells are seen
• the fast and slow fiber areas are reduced about 28% and 21%, respectively
• rare and small foci of necrosis and regeneration accompanied by inflammatory cells are seen
• rare and small foci of necrosis and regeneration accompanied by inflammatory cells are seen
• muscle mass is reduced in mutant mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive limb-girdle muscular dystrophy type 2A DOID:0110275 OMIM:253600
J:91206


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory